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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF4B
All Species:
23.94
Human Site:
S518
Identified Species:
43.89
UniProt:
Q13523
Number Species:
12
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13523
NP_003904.3
1007
116973
S518
G
M
K
V
E
Q
E
S
S
S
D
D
N
L
E
Chimpanzee
Pan troglodytes
XP_518214
1087
126250
S598
G
M
K
V
E
Q
E
S
S
S
D
D
N
L
E
Rhesus Macaque
Macaca mulatta
XP_001094163
1007
116833
S518
G
M
K
V
E
Q
E
S
S
S
D
D
N
L
E
Dog
Lupus familis
XP_848551
1042
120804
E552
E
G
M
K
V
E
Q
E
S
S
S
D
D
N
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61136
1007
116929
S518
G
M
K
V
E
Q
E
S
S
S
D
D
N
L
E
Rat
Rattus norvegicus
Q5RKH1
1007
116988
S518
G
M
K
V
E
Q
E
S
S
S
D
D
N
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508424
1011
117270
E521
E
G
M
K
A
E
Q
E
S
S
S
D
E
N
L
Chicken
Gallus gallus
XP_001232309
1005
116507
S517
M
K
A
E
Q
E
S
S
S
D
E
N
L
E
D
Frog
Xenopus laevis
NP_001088314
991
115012
S503
G
M
K
I
E
Q
E
S
S
D
D
N
L
E
D
Zebra Danio
Brachydanio rerio
NP_998614
1010
116034
E534
M
E
D
F
D
A
E
E
E
D
E
E
A
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_612010
907
104024
C501
T
P
S
P
T
M
P
C
P
N
P
L
I
S
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_492008
775
90931
N411
G
F
D
M
F
A
D
N
E
E
L
P
Q
D
S
Sea Urchin
Strong. purpuratus
XP_791787
924
105587
E488
D
L
D
E
E
E
D
E
E
A
V
I
E
R
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.6
99
95.3
N.A.
95.1
95.4
N.A.
93
89.7
80.6
68.8
N.A.
41.4
N.A.
36.8
48.3
Protein Similarity:
100
92.6
99.3
96.1
N.A.
97.5
97.8
N.A.
96.5
94
89.4
78.4
N.A.
57.4
N.A.
51.9
59.9
P-Site Identity:
100
100
100
20
N.A.
100
100
N.A.
20
13.3
60
13.3
N.A.
6.6
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
40
N.A.
100
100
N.A.
33.3
46.6
80
33.3
N.A.
13.3
N.A.
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
8
16
0
0
0
8
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
8
0
24
0
8
0
16
0
0
24
47
54
8
8
16
% D
% Glu:
16
8
0
16
54
31
54
31
24
8
16
8
16
16
47
% E
% Phe:
0
8
0
8
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
54
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
0
0
8
8
0
8
% I
% Lys:
0
8
47
16
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
0
0
0
0
0
0
0
0
8
8
16
47
16
% L
% Met:
16
47
16
8
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
8
0
16
39
16
0
% N
% Pro:
0
8
0
8
0
0
8
0
8
0
8
8
0
0
0
% P
% Gln:
0
0
0
0
8
47
16
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% R
% Ser:
0
0
8
0
0
0
8
54
70
54
16
0
0
8
8
% S
% Thr:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
39
8
0
0
0
0
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _